The TUC currently is made up of EIGHTEEN NATIONAL UNIONS which are constituted mainly along industrial sectors. These national unions which are affiliates of the TUC are:
- General Agricultural Workers’ Union (GAWU)
- Ghana Mine Workers’ Union (GMWU)
- Public Services Workers’ Union (PSWU)
- Maritime and Dock-workers’ Union (MDU)
- Construction Building & Material Workers’ Union ( CBMWU)
- Timber and Wood-workers’ Union (TWU)
- Railway Workers’ Union (RWU)
- Public Utility Workers’ Union (PUWU)
- General Transport, Petroleum and Chemical Workers’ Union (GTPCWU)
- Teachers and Educational Workers’ Union (TEWU)
- Railway Engine-men’s Union (REU)
- Communications Workers’ Union (CWU)
- Local Government Workers’ Union (LGWU)
- National Union of Seamen (NUS)
- Health Services Workers’ Union (HSWU)
- Ghana Private Road Transport Union (GPRTU)
- Union of Industry, Commerce & Finance Workers’ (UNICOF)
- Federation of Universities Snr. Staff Association of Ghana ( FUSSAG)

