The TUC currently is made up of SEVENTEEN NATIONAL UNIONS which are constituted mainly along industrial sectors. These national unions which are affiliates of the TUC are:

1. General Agricultural Workers' Union (GAWU)
2. Ghana Mine Workers' Union (GMWU)
3. Public Services Workers' Union (PSWU)
4. Maritime and Dock-workers' Union (MDU)
5. Construction and Building Workers' Union (CBWU)
6. Timber and Wood-workers' Union (TWU)
7. Railway Workers' Union (RWU)
8. Public Utility Workers' Union (PUWU)
9. General Transport, Petroleum and Chemical Workers' Union (GTPCWU)
10. Teachers and Educational Workers' Union (TEWU)
11. Railway Engine-men's Union (REU)
12. Communications Workers' Union (CWU)
13. Local Government Workers' Union (LGWU)
14. National Union of Seamen (NUS)
15. Health Services Workers' Union (HSWU)
16. Ghana Private Road Transport Union (GPRTU)
17. Union of Industry, Commerce & Finance Workers' (UNICOF)

The central TUC has its own organs which administer and harmonise the work of all trade unions.